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Sharan Srinivasan, M.D. Ph.D
Sharan Srinivasan, M.D. Ph.D
Assistant Professor
Email: sharans@med.uich.eduPhone: 734-615-8116Assistant Professor
Dr. Srinivasan completed his MD, PhD at the University of Michigan, where he stayed to complete his residency in general neurology. He then completed a Movement Disorders Fellowship at Mass General Brigham (Harvard) before returning to Michigan as faculty. Currently, he co-directs the UM Ataxia Center of Excellence, and is site-PI for UM as part of the Clinical Research Consortium for the Study of Cerebellar Ataxias (CRC-SCA). The Srinivasan Laboratory focuses on studying degenerative cerebellar ataxias with the goal of discovering and developing novel therapeutics. His goal is to improve patient care through innovative approaches.
Lisa M. Sharkey, Ph.D.
Lisa M. Sharkey, Ph.D.
Research Assistant Professor, Neurology
Email: lisams@umich.eduPhone: 734-615-6156Research Assistant Professor, Neurology
Dr. Sharkey completed her Ph.D in Neuroscience at the University of Wisconsin-Madison. She has completed 2 postdoctoral fellowships studying the molecular mechanisms of neurological disease at the Scripps Research Institute in La Jolla, CA, Department of Molecular and Cellular Neuroscience, and at the University of Michigan in the Department of Human Genetics. In her current position in Dr. Paulson's laboratory she is interested in studying the mechanisms of neurodegeneration underlying two common forms of dementia: Alzheimer's Disease and Frontotemporal Dementia (FTD). Ubiquillin2 (Ub2) is a member of a family of proteins containing ubiquitin-like domains that has been implicated in the trafficking of proteins tagged for degradation to the proteasome. Mutations in Ub2 have been shown to cause FTD and Amyotrophic Lateral Sclerosis (ALS). In order to investigate the function of this poorly understood protein, Dr. Sharkey has developed transgenic mouse lines expressing WT and mutant forms of Ub2. Her goal is to use these mice to understand the cellular role of Ub2 in protein quality control both in health and disease states.
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